Moreover, when binding to P2X7 receptors on DCs, ATP stimulates the assembly of NLRP3 inflammasome, and initiates a series of downstream events that ultimately result in the production and release of IL-1β, a cytokine required for the priming of IFN-γ producing tumor-specific CD8+ T cells [45–47]. Here, NLRP3 is linked to neoplasm.