Whilst we observed no significant correlation between EDI and any of these cancer hallmarks in grade 3 tumors or tumors of all grades (p > 0.1, ANOVA or Fisher’s exact test; S9 Fig), TP53 mutation demonstrated a significant correlation with disease-specific survival (p < 0.001, HR = 1.85, 95% CI 1.29–2.65) in grade 3 tumors (Fig 4A). The gene discussed is TP53; the disease is cancer.