TP53 and cancer: Akin to TP53 mutation, copy number loss of 4p14 and 5q13 was able to substratify EDI-high, grade 3 cancer patients into aggressive subgroups (4p14 loss, n = 12, 9% 5-y survival; 5q13 loss, n = 14, 32% 5-y survival; Fig 5B and 5C).