MME and melanoma: However, previous and our current studies suggest that CD10 in tumor cells are playing an important role in melanoma progression; in our previous study [3], we showed that tumoral expression of CD10 was significantly associated with worse prognostic factors such as higher Breslow thickness and ulceration, as well as shorter patient survival; our current in vitro cell proliferation assay and apoptosis assay as well as xenograft experimental study further support this idea by using CD10-transfected melanoma cells.