Having established that multiple independent CDK1 siRNA duplexes caused CDK1 silencing and KRAS selectivity (Fig 3C and 3D and S4B Fig), we assessed cell growth inhibition in a panel of 20 genetically diverse colorectal tumour cell line models transfected with multiple different CDK1 siRNAs (S2 Table). This evidence concerns the gene KRAS and colorectal neoplasm.