That same year, Fecci et al. reported their findings that while absolute CD4+ cell counts (including CD4+ T helper cells and CD4+CD25+FoxP3+CD4RO+ Tregs) were lower in malignant glioma samples compared to controls, Tregs represented an increased fraction of the existing T cells, and though diminished in number, they were sufficient to significantly impair immune responsiveness [53]. This evidence concerns the gene CD4 and malignant glioma.