HAVCR2 and neoplasm: Both Gal-9 and transgenic TIM-3 overexpression have been shown to induce MDSC expansion, with subsequent T cell inhibition [92]; conversely, tumor growth was found to be significantly delayed in TIM-3(−/−) mice implanted with T1 mammary adenocarcinoma, as compared to TIM-3+ wild type mice [92].