As depicted in Figure 2(c), compared to HFD-fed Apoe−/− mice, the levels of pAkt, GSK3, GLUT4, and BG were increased and the level of FOXO was reduced in HFD-fed Apoe−/− mice with VitB6, further supporting the notion that VitB6 improves insulin resistance in mice. Here, APOE is linked to Insulin resistance.