SDC1 and Miyoshi myopathy: We also reported the in vivo antitumor activity of synthetic miR-29b mimics in the context of the BMM, by using the SCID-synth-hu model [103]; in this system, CD138+ cells from advanced MM patients are injected in SCID mice implanted with a 3D polymeric scaffold mimicking the bone architecture, which is previously reconstituted with human BMSCs.