Further studies indicated that the BMM might be involved in downregulation of miR-15a/-16: in fact, IL-6 produced by BMSCs was responsible for miR-15/-16 downregulation by BMSCs, and exogenous IL-6 induced a time- and dose-dependent reduction of miR-15a/-16 in MM cells; in addition, miR-15a inhibition rescued VEGF expression and contributed to disease progression [81, 82]. This evidence concerns the gene IL6 and Miyoshi myopathy.