MM cell adhesion to BMSCs also promotes NF-κB-dependent production of BAFF, a member of the TNF protein superfamily, crucial for the maintenance and homeostasis of normal B-cell development, which confers a survival advantage on MM cells [37, 38] and promotes RANK-Lindependent osteoclastogenesis [39]. The gene discussed is TNFSF13B; the disease is Miyoshi myopathy.