Adhesion to BMSCs or exogenous cytokines (IL-6, IGF-1, and HGF) did not affect the in vitro tumor suppressive activity of synthetic miR-125b-5p mimics that was also confirmed in vivo after delivery of lipid-emulsion formulated oligonucleotides in SCID mice bearing MM xenografts [23]. This evidence concerns the gene HGF and Miyoshi myopathy.