They clearly demonstrated that (1) HR-MM cells secreted a bigger amount of exosomes, as compared to isogenic cells; (2) exosomes derived from HR-MM cells induced tube formation in both normoxic and hypoxic HUVECs; (3) miRNA content differed between exosomes released from HR-MM cells and isogenic nonhypoxia resistant cells; (4) enhanced tube formation by HR-MM cell exosomes in HUVECs was mediated by exosomal miR-135b, which strengthened HIF-1α transcriptional activity by directly targeting hypoxia-inducible factor-1α subunit inhibitor FIH-1 [124]. This evidence concerns the gene HIF1A and Miyoshi myopathy.