Agarwal et al. [10] reported that PGE2 upregulated the p-ERK and p-AKT levels, suggesting the involvement of ERK and AKT pathways in the 12-lipoxygenase- (LOX-) and cyclooxygenase- (COX-) 2-mediated regulation of growth in a human epidermoid carcinoma cell line (A431 cells). Here, AKT1 is linked to squamous cell carcinoma.