LEP and congenital secretory chloride diarrhea 1: Cases of CLD caused by mutations in the leptin gene are rare: to date, a total of 38 individuals of Turkish (n = 6) [5, 33–35], Pakistani (n = 27) [31, 36–40], Austrian (n = 1) [41], Egyptian (n = 2) [14], Russian (n = 1) [42], and Indian (n = 1) [43] origins, harboring different mutations in the leptin gene, have been reported.