Importantly, genes encoding receptors for interferons (interferon-α receptor 1 (IFNAR1), IFNAR2, and IFN-γ R2 (IFNGR2)) responsible for activating JAK-STAT signaling cascades were found to be located on HSA21 and are triplicated in DS [23], suggesting a potential dysregulation of the downstream JAK-STAT signaling leading to activation of gliogenesis in DS brain. This evidence concerns the gene IFNGR2 and Dravet syndrome.