BDNF and early-onset autosomal dominant Alzheimer disease: Long-term treatment (24 h) with amyloid-beta(1-42) as well as long-term treatment with amyloid-beta(3(pE)-42) which has been discussed recently to be a potential player in triggering Alzheimer's disease [82] affected anterograde as well as retrograde transport of BDNF (Figure 4).