This transgenic mouse line was engineered to overexpress Aβ(1-42) [32, 34] by coexpressing amyloid precursor protein (APP) with three familial Alzheimer's disease (FAD) mutations and presenilin 1 (PS1) with two FAD mutations which additionally increases Aβ(1-42) production. The gene discussed is PSEN1; the disease is familial Alzheimer disease.