On the other hand, chitotriosidase has been implicated in the pathogenesis of many human diseases through the improper induction of inflammation and faulty tissue remodeling such as bronchial asthma, chronic obstructive pulmonary disease (COPD), nonalcoholic fatty liver disease, and neurodegenerative disorders like Alzheimer's disease and amyotrophic lateral sclerosis [19, 21–24]. Here, CHIT1 is linked to metabolic dysfunction-associated steatotic liver disease.