The intraperitoneal administration of 200 mg/kg of cactus polysaccharides, the active component isolated from Opuntia dillenii, prior to the middle cerebral artery occlusion showed neuroprotective effects [170, 171]. Opuntia dillenii significantly reduced infarct volume, decreased neuronal loss in the cerebral cortex, and diminished importantly the nitric oxide synthase (NOS) synthesis, which is usually induced during the experimental period of reperfusion and ischemia [171]. Here, NOS2 is linked to ischemia.