Although neither ALT nor AST showed significant correlations with serum GSSG concentrations in both HCV-monoinfected and HIV/HCV-coinfected patients (data not shown), HIV infection of subjects with abnormal (>40 IU/L) AST and ALT levels was associated with significant increases in serum GSSG, both in chronic HCV carriers (P = 0.045 for ALT and P = 0.014 for AST) and in HCV resolvers (P = 0.022 for ALT and P = 0.008 for AST) (Figure 3). The gene discussed is GPT; the disease is HIV infectious disease.