CS and Alzheimer disease: At variance, AD group showed only a slight, but statistically significant increase of cytochrome C oxidase activity (median ± SEM; CTL 0.035 ± 0.0015 units oxidized/mL/min versus AD 0.15 ± 0.014 units oxidized/mL/min; p < 0.05), whereas no differences were observed in AD citrate synthase activity compared to controls (Figures 2(a) and 2(b)).