It does not appear to be associated with or dependent on the angiotensin converting enzyme 2 (ACE2) and angiotensin (1–7) (Ang(1–7)) axis [27], and despite known renal actions of AngII given at higher doses, we have repeatedly reported no chronic changes in sodium or water balance using this model of hypertension [17, 19, 21]. The gene discussed is AGT; the disease is hypertensive disorder.