This is the reversal face of the “metabolic memory” phenomenon observed in diabetic patients, a concept that came from the Diabetes Control and Complications Trial-Epidemiology of Diabetes Interventions and Complications (DCCT-EDIC) research: several studies demonstrated a slower progression of diabetic complications in the group of patients who have received intensive insulin treatment, a persistent benefit more than 10 years after the end of the treatment [21–23]. The gene discussed is INS; the disease is diabetes mellitus.