Previous study demonstrated that the JNK pathway in pancreatic cancer stem cells (CSCs) is upregulated and the JNK pathway inhibition can increase the intracellular ROS induced by chemotherapeutic agents such 5-FU and gemcitabine (GEM), indicating an important role for ROS in increasing chemosensitivity [34]. The gene discussed is MAPK8; the disease is familial pancreatic carcinoma.