A possible explanation of this finding implies the Amyloid Precursor Protein (APP); the APP gene, in fact, was found upregulated in the case of complex karyotype AML and in those chromosomal rearrangements involving chromosome 21q21, where the gene is located [63]; a fraction of t(8;21) AML patients, then, has been linked to higher probability to develop granulocytic sarcoma and to lower long-term survival based on their level of APP expression [64]. This evidence concerns the gene APP and acute myeloid leukemia.