Later evidence, though, showed how mixed lineage leukemia (MLL) fusion proteins, produced by translocations involving chromosome 11q23, are sufficient per se to confer self-renewal ability and L-IC properties to committed hematopoietic progenitors (HPP), as evidenced by the capacity of experimentally engineered MLL+ committed granulocyte/macrophage progenitors (GMP) to serially transfer leukemia to secondary recipient mice [30]. Here, KMT2A is linked to leukemia.