RUNX1 and acute myeloid leukemia: Core Binding Factor (CBF) Acute Myeloid Leukemia (AML) is cytogenetically defined by the presence of the t(8;21)(q22;q22) or the inv(16)(p13q22)/t(16;16)(p13;q22) [1], alterations that lead to the formation of fusion genes (runt-related transcription factor 1 (RUNX)/RUNX1T1 and CBFB/myosin heavy chain 11 (MYH11), resp).