Recent investigation has found a specific myeloid cell population that in response to the granulcyte colony-stimulating factor (G-CSF), IL-6, and CXCL12 factors, secreted by tumor cells and stroma, is mobilized and migrates to tumor site, thus mediating tumor angiogenesis and resistance to anti-VEGF therapy [140]. Here, CXCL12 is linked to neoplasm.