The activity of VEGF is also increased by the aberrant activation of multiple growth factor receptors in malignant glioma, including EGFR platelet-derived growth factor receptor (PDGFR), scatter factor/hepatocyte growth factor receptor (MET), IGF receptor (IGFR), stem cell factor receptor (c-Kit), and FGF receptor (FGFR), and by the deregulation of signaling pathway such as phosphatidylinositol 3-kinase (PI3K/Akt) and Ras/MAPK pathways [141]. Here, VEGFA is linked to malignant glioma.