Treatment of the Apcmin/+ colon cancer mouse model with 1,25(OH)2D3 or analogs reduces polyp number and load, while it increases E-cadherin levels and reduces β-catenin nuclear localization and the expression of the β-catenin target genes Tcf1, Myc, and Cd44 in the small intestine and colon [32]. The gene discussed is CDH1; the disease is colonic neoplasm.