Remarkably, elevated VDR expression is associated with high tumor differentiation, absence of node involvement, and good prognosis in colon cancer [93–95], with lower tumor grade, late development of lymph node metastases, and longer disease-free survival in breast cancer [43, 96–98], and with improved overall survival in prostate and non-small cell lung cancer and melanoma [99–101]. This evidence concerns the gene VDR and malignant colon neoplasm.