Consistently with its inhibitory effect on EMT, 1,25(OH)2D3 downregulates the secretion of MMP2, MMP9, and MMP13 in prostate, breast, pancreatic, and squamous cell carcinoma cells and increases TIMP1 and TIMP2 activity in prostate and breast cancer cells [39, 42, 48, 59–61]. This evidence concerns the gene MMP13 and breast cancer.