Kaler et al. found that colon cancer cells stimulate tumor-associated macrophages to secrete interleukin- (IL-) 1β, which in turn promotes Wnt/β-catenin signaling, stabilizes SNAIL1 protein, and confers resistance to TRAIL-induced apoptosis in colon cancer cells [71]. Here, TNFSF10 is linked to colonic neoplasm.