In addition to colon cancer, E-cadherin is induced by 1,25(OH)2D3 or analogs in normal mammary and bronchial epithelial cells and in tumor cell lines derived from breast, prostate, non-small cell lung, and squamous cell carcinomas, usually associated with an increase in epithelial differentiation, a reduction in cell migration and invasion, and the inhibition of Wnt/β-catenin signaling [35–41, 61, 77, 78]. The gene discussed is CDH1; the disease is malignant colon neoplasm.