However, Lazarova et al. reported that ZEB1 binds to two distal E-boxes in the murine Vdr promoter and activates its expression in COS-7 monkey kidney fibroblasts and SW620 human colon cancer cells, but not in human LNCaP prostate or HCT116 colon cancer cells [116]. This evidence concerns the gene ZEB1 and colonic neoplasm.