After Takahashi et al. and Vodyanik et al. induced adult human somatic cells into iPSCs with a series of transcription factors (Oct4, Sox2, Klf4, c-Myc or Oct4, Sox2, Nanog, and Lin28), the transplantation of DA neurons for PD patients had become more feasible and easily operable. Here, SOX2 is linked to Parkinson disease.