KLF4 and glioblastoma: In addition KLF4, a well-known pluripotency factor [32] which is implicated in glioblastoma stem cells proliferation, migration, and invasion [33] has also been demonstrated to physically interact with p65, a member of the NF-κB family of transcription factors involved in the regulation of a wide variety of biological responses and with a pivotal role in oncogenesis [34], in the induction of a macrophage-mediated proinflammatory pathway activation [35].