These cells are used to stimulate angiogenesis by the expression of growth factors (vascular endothelial growth factor (VEGF), fibroblast growth factor, hepatocyte growth factor, granulocyte-colony stimulating factor, and angiopoietin-1 (Angpt-1)) [64–66] via a local paracrine mechanism in response to ischemia. The gene discussed is VEGFA; the disease is ischemia.