Our findings support the viewpoint of the study on lung adenocarcinoma that the prognostic impact of loss of CADM1/TSLC1 was significant for male patients but not for female patients [4], since it has been widely recognized that the prognosis of men and women with ESCC is distinct and TSLC1 might be one of the genes that play a different role in men and women with ESCC. The gene discussed is CADM1; the disease is esophageal squamous cell carcinoma.