CD4 and inflammatory bowel disease: Mouse models of colitis induced by AdTr of CD25− depleted CD4+ T cells are highly suitable for pharmacological testing of new IBD drug candidates because they are easy and fast to perform (compared to other chronic models, e.g., SAMP-1/Yit) [7, 8], there is no generation of anti-drug antibodies, and it results in uniform and highly reproducible clinical and pathological signs of colitis [9].