In order to study IBD and evaluate anti-inflammatory strategies, a variety of animal models have been developed and are traditionally divided into those with spontaneous development of colitis due to genetic manipulation (e.g., targeted deletion of the anti-inflammatory cytokine IL-10), chemically induced colitis (e.g., dextran sulfate sodium (DSS)), hapten-induced colitis (e.g., 2,4,6-trinitrobenzene sulfonic acid (TNBS)), and adoptive transfer (AdTr) models (transfer of T cells from a donor mouse to a T cell deficient mouse) [5]. This evidence concerns the gene IL10 and colitis.