Kumar et al. [3] have reported that the blocking of cox-2 activity in cAD rats by valdecoxib (specific cox-2 inhibitor) resulted in better recovery of memory impairment, oxidative stress, and acetylcholine esterase activity compared to that of nonspecific cox blocker, naproxen, in a 25-day study indicating an important role of cox-2 on the colchicine induced memory impairments and stress parameters. Here, ACHE is linked to memory impairment.