ALK and cancer: During the initiation and development of NSCLC, driver genes that induce and maintain molecular changes of malignant tumors, such as epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), fibroblast growth factor receptor 1 (FGFR1), and phosphoinositide 3-kinase catalytic subunit A (PIK3CA), play an important role [8].