This identified 56 functional variants that formed 12 haplotypes of which HAP3 was strongly associated with SLE susceptibility (OR 2.0, p<7.04 E-08) while HAP1 (OR 0.58, p<1.63 E -06) and HAP6 (OR 0.34, p<1.69 E-07) were protective (Figure 5D,E, Supplementary file 2). The gene discussed is NFYB; the disease is systemic lupus erythematosus.