Finally, three risk loci, CCL22-CX3CL1 (Figure 11.iii), ZGLP1-RAVER1 (Figure 11.iv), and ICA1 (Figure 12.i), which were comparatively less well-studied for SLE association, were detected with strong statistical associations in this EA cohort (Table 1, Supplementary file 2). This evidence concerns the gene RAVER1 and systemic lupus erythematosus.