DBI and obesity due to melanocortin 4 receptor deficiency: Further supporting the role of Dbi/Acbp products in energy balance, a study conducted in humans by Comuzzie and collaborators (Comuzzie et al., 2012), indicates that DBI/ACBP single nucleotide polymorphism (SNP) was associated with obesity, supporting the relevance of the DBI/ACBP production in energy homeostasis.