LCN2 and Sepsis: High plasma NGAL was also observed that could independently predict mortality (AUC = 0.64) and multiple organ dysfunction syndrome in severe sepsis and septic shock during ICU stay (hazard ratio = 2.13; 95 % CI: 1.08–4.20; P = 0.03 and hazard ratio = 1.90; 95 % CI: 1.01–3.55; P = 0.046, respectively) [48].