After adjusting for relevant confounders, logistic regression analysis showed that the Klotho G-395A SNP was significantly associated with high blood pressure (OR 0.47, 95 % CI 0.25 to 0.90) and low HDL-C (OR 0.69, 95 % CI 0.27 to 0.93) (Table 3). This evidence concerns the gene KL and hypertensive disorder.