KL and hypertensive disorder: After adjusting for relevant confounders, logistic regression analysis showed that the Klotho G-395A SNP was significantly associated with high blood pressure (OR 0.47, 95 % CI 0.31 to 0.71) and hypertriglyceridemia (OR 0.54, 95 % CI 0.31 to 0.98) (Table 3).