KL and hypertensive disorder: After adjusting for relevant confounders, logistic regression analysis revealed that the Klotho G-395A SNP was significantly associated with high blood pressure (OR 0.48, 95 % CI 0.34 to 0.67) and hypertriglyceridemia (OR 0.66, 95 % CI 0.39 to 0.95) (Table 3).