The mean (SD) differences of serum ACE levels between the patients with presumed sarcoidosis and AS, BD, presumed latent TB, presumed latent syphilis and control group were 28.907 (3.735), 26.784 (3.770), 25.776 (3.898), 27.821 (6.155), and 37.016 (4.918) U/L respectively. This evidence concerns the gene ACE and sarcoidosis.