The estimated marginal mean values of serum ACE level for the patients with AS, BD, presumed latent TB and presumed latent syphilis were 29.360, 31.392, 32.500 and 30.452 U/L respectively which were lower than the estimated marginal mean value of ACE for presumed sarcoidosis, but higher than the estimated marginal mean value of ACE for control group (Fig. 1). This evidence concerns the gene ACE and latent syphilis.