Many E2 regulated genes in other normal and cancer cell types were also regulated in MOE cells including Pgr, Greb1, Csf2, and Dhrs9 [43, 44], while other E2 regulated genes in MCF7 cells were not regulated (Nrip1) [35] or even expressed (Tff1) in MOE cells [45]. This evidence concerns the gene GREB1 and cancer.