When we treated cells with EGCG before HCV dsRNAs stimulation, the HCV dsRNAs-induced IFN-λ1, RIG-I, TLR3 and several antiviral ISGs (ISG15, MxA) expressions were significantly enhanced, indicating that EGCG might be used as an agent to enhance the innate immune responses during viral infections. Here, TLR3 is linked to viral infectious disease.