Interestingly, BCORL1 knockdown decreased the levels of vimentin and N-cadherin, two EMT-related mesenchymal markers, in HCCLM3 cells (P < 0.05, respectively, Fig. 4d), while BCORL1 overexpression increased the expressions of vimentin and N-cadherin in Hep3B cells (P < 0.05, respectively, Fig. 4f), indicating BCORL1 affected EMT in HCC cells. This evidence concerns the gene CDH2 and hepatocellular carcinoma.