As none of the other 52 variants resided in genes that were putatively candidates for causing EDS, we considered the (c.1261G > A, p. Gly421Ser) variant in the ADAMTSL2 gene to be the most likely causative source of EDS in the family as it segregated in keeping with a disease-causing variant in this family. Here, ADAMTSL2 is linked to Ehlers-Danlos syndrome.