A number of serum biomarkers of inflammatory and proteolytic activity have been investigated in patients with AAA including MMPs (MMP-2, MMP-8, MMP-9), interleukins (IL-6, IL-10), CRP and other potential mediators (including TNF-α and TIMP-1) that may contribute to connective tissue degradation and depletion of collagen and elastin stores. This evidence concerns the gene MMP8 and triple-A syndrome.