To confirm the results obtained in vitro, the two MO sequences were further evaluated in vivo, in the B6.Cg-Tg(SOD1-G93A)1Gur/J transgenic ALS mouse model, which carries a high copy number of the mutant human SOD1 allele containing the G93A mutation. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.