For example, antiapoptotic BCL2L1, RFFL (which negatively regulates p53, CASP8 and CASP10 through proteasomal degradation), ATG4B (required for autophagy), and MKL1 (which suppresses TNF-induced cell death by inhibiting caspase activation) were up-regulated in p63+ DLBCL compared with p63− DLBCL, whereas C13orf15/RGCC (in response to DNA damage) was downregulated in p63+ DLBCL patients (Table 4). The gene discussed is RFFL; the disease is diffuse large B-cell lymphoma.