TP53 and cancer: Additionally, different mutants exhibit distinct transactivation patterns that are directly connected with disparate phenotypes.2, 3, 4 More importantly, studies involving various cancer patients revealed that different p53 mutations were associated with diverse prognostic values.5 While hot spots like R273H and R248 have been intensively investigated,6, 7, 8 studies concerning R282W have been relatively limited (in this case, R282W designates an arginine mutated to a tryptophan at position 282 in the p53 protein).