5-Amino-4-imidazole carboxamide riboside (AICAR), which is a pharmacological activator of AMPK, stimulated extracellular FASN release in breast cancer cells;26 therefore, we investigated the role of AMPK signalling in FASN and SREBP-1 expression in PCa cells treated with AICAR. The gene discussed is FASN; the disease is breast cancer.