INS and breast carcinoma: At the same time, tumors without such a constitutive activation were stimulated by insulin and IGF-1, and responded to CR with increased rates of apoptosis mediated through FOXO1.63 This is reminiscent of the classical studies of the 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma of the rat by Heuson and Legros.