HDAC3 and cancer: LncRNA-LET is reported to be downregulated in many types of tumour tissues, including cancers of the gallbladder,31 and liver.32, 33 Yang et al.33 demonstrated that hypoxia-induced histone deacetylase 3 repressed lncRNA-LET by reducing the histone acetylation-mediated modulation of the lncRNA-LET promoter region.