PTEN and Familial prostate cancer: It is downregulated in non-small cell lung cancer38 but upregulated in hepatocellular carcinoma.39 Linc00963 is only reported in prostate cancer, where it affects cellular progression.40 PTENP1 has been reported in the literature to have a suppressive role in cell growth by regulating cellular levels of PTEN.41 However, in contrast to the expression levels in tissue, PVT1 and linc00963 in serum were significantly lower in ccRCC patients than in controls.