Alterations in circadian behavior observed in mice deficient in either RORα or RORβ receptor [122, 124, 216] and associations between SNPs in RORA and RORB with an increased risk for several neuropsychiatric disorders, including autism spectrum (ASD) and bipolar disorder, schizophrenia, depression, and posttraumatic stress syndrome [106–117, 129, 130], would be consistent with a link between disturbance in the circadian rhythm and these pathologies. Here, RORA is linked to depressive disorder.