The antifibrotic properties of DPP-4 inhibitors have also been shown in other models of kidney fibrosis, such as the unilateral ureteral obstruction (UUO) model, where the administration of a novel DPP-4 inhibitor, LC15-0444, resulted in a significant decrease in albuminuria, the urinary excretion of 8-isoprostane, and renal fibrosis [65]. Here, DPP4 is linked to renal fibrosis.