AKR1A1 and breast cancer: In addition, clinical studies have reported a correlation between moderate ethanol intake (15–30 g/day) and increased risk of breast cancer in the premenopausal women group homozygous for the alcohol dehydrogenase 31 alelle (ADH31−1); phenotype that be characterize by an activity increased of alcohol dehydrogenase and thus a major production of acetaldehyde from ethanol [19].