NFKB1 and hypertensive disorder: The consistent changes between NF-κB and RAS activity in conduit and resistance arteries, taken together with the finding that RAS activity upregulation was delayed in comparison to NF-κB activation in conduit arteries (Fig. 8), suggest that NF-κB upregulating RAS activity in conduit artery is critical to aortic dysfunction and hypertension development.