In contrast, CD11b (also known as Mac-1), an active constituent of the innate immune response predominately expressed on monocytes/macrophages, granulocytes, myeloid-derived dendritic cells, natural killer cells, microglia, B-1 cells and activated neutrophils, is a more sensitive biomarker of inflammatory cells, which has been reported overexpressed in tumor tissues18, infarcted myocardium, and atherosclerosis plaques19, 20. The gene discussed is ITGAM; the disease is neoplasm.