Immunoblotting showed that both shRNAs lowered CDK2 protein level by 80% ± 5% and the level of active, phosphorylated CDK2 (Thr160) by 70% ± 0.8% 48 h after infection compared to podocytes infected with viruses carrying the empty vector shRNA (Fig. 6A,B,C). The gene discussed is CDK2; the disease is infection.